CJC-1295 + Ipamorelin Blend

Description

Compound Specifications

Component	Quantity	Class	Residues	Molecular weight	CAS
CJC-1295 (no DAC)	5mg	Modified GHRH fragment	29	3367.9 g/mol	863288-34-0
Ipamorelin	5mg	Synthetic pentapeptide	5	711.85 g/mol	170851-70-4

Total peptide content	10mg per vial
Ipamorelin sequence	Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Ipamorelin C-terminus	Amidated
Purity	≥99% per component (HPLC verified)
Form	Lyophilized powder
Storage (lyophilized)	2–8°C, protected from light
Storage (reconstituted)	2–8°C, 30 days
Long-term storage	-20°C
Third-party testing	Freedom Diagnostics
Manufacturing	Arizona GMP facility, USA

Verify molecular weights, sequence and CAS numbers against batch COA. Confirm whether your CJC-1295 batch includes the DAC modification — this changes the molecular weight substantially.

Why These Two Compounds Are Blended

CJC-1295 and Ipamorelin are structurally unrelated. They share no sequence homology, differ in length by a factor of nearly six, and engage entirely different receptors. They are supplied together because that difference is the point — not because they are variations on a theme.

CJC-1295 is a 29-residue sequence derived from the N-terminal fragment of growth hormone-releasing hormone, GRF(1–29), carrying four amino acid substitutions relative to the native fragment. Those substitutions target known enzymatic cleavage sites and sites of chemical instability. It acts at the GHRH receptor.

Ipamorelin is not derived from any natural sequence. It is a fully synthetic pentapeptide built from unusual building blocks: Aib (aminoisobutyric acid, a non-proteinogenic residue), D-2-naphthylalanine and D-phenylalanine — two D-amino acids, the mirror-image stereoisomers of the L-forms found in natural proteins. Its C-terminus is amidated. Every one of those features exists to resist enzymatic degradation, since proteases that recognise natural L-amino acid sequences do not efficiently process D-residues. It acts at the ghrelin receptor (GHS-R1a), a different receptor entirely from CJC-1295’s target.

Two compounds engaging two separate receptors is a distinct experimental design from two compounds engaging the same receptor, and it is the reason this pairing is supplied pre-combined rather than as a variation on either single compound.

A note on DAC. CJC-1295 exists in two forms: with and without a drug affinity complex, a maleimide group that binds serum albumin and substantially extends circulating half-life. The DAC and non-DAC forms have materially different molecular weights and are frequently conflated by suppliers. Check the Certificate of Analysis on anything you purchase.

All statements above describe molecular characteristics and published research contexts. Noxa Labs makes no claim regarding safety, efficacy, or outcomes of any kind, in humans or animals.

Handling & Storage

Lyophilized material is stable at 2–8°C when sealed and shielded from light. For storage beyond several months, -20°C is preferred. Avoid repeated freeze-thaw cycles.

Introduce bacteriostatic water slowly down the inner wall of the vial rather than directly onto the powder. Swirl gently until fully dissolved; do not shake or vortex.

This is a two-component blend with a substantial length disparity — a 29-residue sequence and a 5-residue sequence dissolve at different rates. The short pentapeptide will go into solution well before the longer fragment. Confirm the vial is completely clear before any transfer; apparent dissolution can be misleading here in a way it is not with single-compound vials.

Once in solution, store at 2–8°C and use within 30 days. A 10mg vial reconstituted with 2mL of bacteriostatic water yields 5mg/mL total peptide concentration.

Concentration and volume calculator →

Purity & Testing

Every batch is synthesized at our GMP-compliant Arizona facility and independently analyzed by Freedom Diagnostics before release. For blends, each component is verified separately prior to combination and the finished blend is verified again. Certificates of Analysis are available for any lot; contact us with your order number.

View all Certificates of Analysis →

Frequently Asked Questions

What is in this blend?
CJC-1295 (5mg) and Ipamorelin (5mg), totaling 10mg of peptide content in a single vial.

Does this contain CJC-1295 with or without DAC?
Check the Certificate of Analysis for your specific lot. The two forms have different molecular weights and are commonly confused across the market.

What are D-amino acids and why does Ipamorelin contain them?
D-amino acids are the mirror-image stereoisomers of the L-forms found in natural proteins. Proteases that recognise L-sequences process them poorly, so incorporating D-residues is a standard strategy for resisting enzymatic degradation.

What is Aib?
Aminoisobutyric acid, a non-proteinogenic amino acid. It constrains backbone conformation and is not found in natural protein sequences.

Do the two components target the same receptor?
No. CJC-1295 acts at the GHRH receptor; Ipamorelin acts at the ghrelin receptor, GHS-R1a.

Why does dissolution need extra attention with this blend?
The two components differ substantially in length and dissolve at different rates. The pentapeptide enters solution first; confirm the vial is fully clear before transfer.

Related Research Compounds

• Tesamorelin — 44-residue GHRH analog, separate research class
• Certificates of Analysis — batch testing data

Research Use Only

For Research Use Only. This product is intended solely for laboratory research purposes. It is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as such. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not for resale without authorization.