Semax

Description

Compound Specifications

Compound class	Synthetic ACTH fragment analog
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Single-letter sequence	MEHFPGP
Amino acid count	7
Parent fragment	ACTH(4–7), Met-Glu-His-Phe
C-terminal extension	Pro-Gly-Pro
Molecular weight	813.9 g/mol
CAS number	80714-61-0
Form	Lyophilized powder
Quantity	10mg per vial
Purity	≥99% (HPLC verified)
Endotoxin testing	Performed per batch
Storage (lyophilized)	2–8°C, protected from light
Storage (reconstituted)	2–8°C, 30 days
Long-term storage	-20°C
Third-party testing	Freedom Diagnostics
Manufacturing	Arizona GMP facility, USA

Verify sequence, molecular weight and CAS number against batch COA prior to publication.

Research Background

Semax is a seven-residue synthetic peptide constructed from two distinct parts. The first four residues — Met-Glu-His-Phe — correspond to positions 4 through 7 of adrenocorticotropic hormone, a 39-amino-acid pituitary hormone. The remaining three residues, Pro-Gly-Pro, are not part of the ACTH sequence at all.

That appended tripeptide is the compound’s defining feature. Proline-containing sequences are markedly resistant to exopeptidase activity, because the cyclic side chain of proline constrains the backbone geometry that peptidases require in order to engage a terminus. Flanking a glycine with two prolines produces a C-terminal cap that is difficult to trim enzymatically. The result is a short peptide with far greater stability than a bare four-residue ACTH fragment would possess.

This design approach — taking a biologically characterized fragment and appending a proline-rich stabilizing tail — distinguishes Semax from every other compound in the Noxa Labs catalog. TB-500 is a fragment presented unmodified. Tesamorelin is a full sequence with a chemical group attached at one end. Ipamorelin is built from non-natural residues throughout. Semax is a hybrid: a natural fragment fused to a synthetic stabilizing extension.

The compound originates from Russian pharmacological research conducted from the 1980s onward, and a substantial portion of the literature concerning it is published in Russian. Researchers reviewing published work on this compound should be aware that the English-language literature represents only part of the available material.

All statements above describe molecular characteristics and published research contexts. Noxa Labs makes no claim regarding safety, efficacy, or outcomes of any kind, in humans or animals.

Handling & Storage

Lyophilized Semax is stable at 2–8°C when sealed and shielded from light. For storage beyond several months, -20°C is preferred. Avoid repeated freeze-thaw cycles.

The N-terminal methionine is susceptible to oxidation. Minimize air exposure in solution, keep vials sealed when not in use, and avoid prolonged bench time at room temperature.

Introduce bacteriostatic water slowly down the inner wall of the vial rather than directly onto the powder. Swirl gently until fully dissolved; do not shake or vortex. Short sequences dissolve rapidly — confirm the solution is completely clear and particulate-free before any transfer.

Once in solution, store at 2–8°C and use within 30 days. A 10mg vial reconstituted with 2mL of bacteriostatic water yields a 5mg/mL concentration.

Concentration and volume calculator →

Purity & Testing

Every batch is synthesized at our GMP-compliant Arizona facility and independently analyzed by Freedom Diagnostics before release. We publish HPLC purity data and endotoxin testing results — we don’t ask you to take our word for it. Certificates of Analysis are available for any lot; contact us with your order number.

View all Certificates of Analysis →

Frequently Asked Questions

What is Semax derived from?
The first four residues correspond to positions 4–7 of adrenocorticotropic hormone. The final three residues, Pro-Gly-Pro, are a synthetic addition not found in the ACTH sequence.

What does the Pro-Gly-Pro extension do?
It acts as a stabilizing cap. Proline’s cyclic side chain constrains backbone geometry in a way that resists exopeptidase activity, protecting the peptide from C-terminal degradation.

Is Semax a natural peptide?
Partly. Four of its seven residues correspond to a natural hormone fragment; the remaining three are a synthetic extension. The complete molecule does not occur naturally.

Why does the methionine matter for handling?
Methionine is prone to oxidation. Minimizing air exposure and bench time in solution helps preserve integrity.

Where does the research on this compound come from?
It originates largely from Russian pharmacological research beginning in the 1980s, and much of the published literature is in Russian.

What size is available?
10mg lyophilized vials.

Related Research Compounds

• MOTS-C — 16-residue signaling peptide, separate research class
• Certificates of Analysis — batch testing data

Research Use Only

For Research Use Only. This product is intended solely for laboratory research purposes. It is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as such. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not for resale without authorization.