Retatrutide

Description

Compound Specifications

Compound class	Synthetic peptide — triple receptor agonist
Receptor targets (in vitro)	GLP-1R, GIPR, GCGR
Structural basis	GIP-based backbone with fatty acid modification
Form	Lyophilized powder
Available quantities	5mg, 10mg, 20mg, 30mg, 40mg, 60mg per vial
Purity	≥99% (HPLC verified)
Endotoxin testing	Performed per batch
Storage (lyophilized)	2–8°C, protected from light
Storage (reconstituted)	2–8°C, 30 days
Long-term storage	-20°C
Third-party testing	Freedom Diagnostics
Manufacturing	Arizona GMP facility, USA

Molecular weight, molecular formula and CAS number to be populated from batch COA prior to publication.

Research Background

Retatrutide belongs to a class of engineered peptides described in the literature as multi-receptor agonists — single molecules designed to interact with more than one incretin-family receptor simultaneously. Where earlier compounds in this research area engaged a single receptor, and later dual agonists engaged two, Retatrutide is characterized as engaging three: the glucagon-like peptide-1 receptor, the glucose-dependent insulinotropic polypeptide receptor, and the glucagon receptor.

The structural approach involves a modified peptide backbone with a fatty acid chain attached, a design feature used across this compound class to extend circulating half-life through albumin binding. This is a formulation-level characteristic rather than a receptor-level one, and it is the reason compounds in this family are studied on extended dosing intervals in preclinical models.

The addition of glucagon receptor activity is what distinguishes Retatrutide from dual-agonist compounds in the same research area, and it is the principal variable examined in comparative preclinical literature.

Retatrutide is an investigational compound. It is not approved by the FDA or any other regulatory authority for any use. All references above describe published preclinical and laboratory research contexts. Noxa Labs makes no claim regarding safety, efficacy, or outcomes of any kind, in humans or animals.

Handling & Storage

Lyophilized Retatrutide is stable at 2–8°C when sealed and shielded from light. For storage beyond several months, -20°C is preferred. Avoid repeated freeze-thaw cycles, which degrade peptide integrity.

For solution preparation, introduce bacteriostatic water slowly down the inner wall of the vial rather than directly onto the powder — direct impact can shear the peptide chain. Swirl gently until fully dissolved. Do not shake or vortex. The resulting solution should be clear and free of particulates; cloudiness or visible precipitate indicates a handling failure and the vial should be discarded.

Fatty-acid-modified peptides are more sensitive to agitation than unmodified sequences. Handle accordingly.

Once in solution, store at 2–8°C and use within 30 days.

Concentration and volume calculator →

Purity & Testing

Every batch is synthesized at our GMP-compliant Arizona facility and independently analyzed by Freedom Diagnostics before release. We publish HPLC purity data and endotoxin testing results — we don’t ask you to take our word for it. Certificates of Analysis are available for any lot; contact us with your order number.

View all Certificates of Analysis →

Frequently Asked Questions

What receptors does Retatrutide act on?
Published literature characterizes it as an agonist at three receptors: GLP-1, GIP, and glucagon. This triple activity is what distinguishes it from single- and dual-agonist compounds in the same research class.

Is Retatrutide an approved medication?
No. Retatrutide is an investigational compound and is not approved by the FDA or any other regulatory authority for any use. This product is supplied for laboratory research purposes only.

What is the fatty acid modification for?
It is a half-life extension strategy common to this compound class. The fatty acid chain promotes albumin binding, which slows clearance in preclinical models.

What sizes are available?
5mg, 10mg, 20mg, 30mg, 40mg, and 60mg lyophilized vials.

How is it shipped and stored?
Lyophilized peptide is shelf-stable in transit and ships in discreet packaging from Arizona. Refrigerate at 2–8°C on arrival.

Is a Certificate of Analysis available?
Yes, for every lot. Contact us with your order number and we will provide the HPLC and endotoxin data for your specific batch.

Related Research Compounds

• Tesamorelin — GHRH analog, a separate research class
• MOTS-C — mitochondrial-derived peptide
• Certificates of Analysis — batch testing data

Research Use Only

For Research Use Only. This product is intended solely for laboratory research purposes. It is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as such. Retatrutide is an investigational compound not approved by the FDA for any indication. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not for resale without authorization. No representation is made regarding safety or efficacy.